糖皮质激素对分离的骨骼肌中蛋白质合成与蛋白质分解的作用。
Glucocorticoid action on protein synthesis and protein breakdown in isolated skeletal muscles.
作者信息
McGrath J A, Goldspink D F
出版信息
Biochem J. 1982 Sep 15;206(3):641-5. doi: 10.1042/bj2060641.
Abstract
The direct actions of glucocorticoid hormones on protein turnover were studied in isolated soleus muscles. These steroids were found to decrease the rates of both protein synthesis and protein breakdown within 3 h and 4 h respectively. Synthetic steroids (e.g. dexamethasone) were found to be more potent than naturally secreted hormones (e.g. cortisol) in inducing these changes, but only at concentrations in vitro less than 10nm.
摘要
在分离的比目鱼肌中研究了糖皮质激素对蛋白质周转的直接作用。发现这些类固醇分别在3小时和4小时内降低蛋白质合成和蛋白质分解的速率。发现在诱导这些变化方面，合成类固醇（如地塞米松）比天然分泌的激素（如皮质醇）更有效，但仅在体外浓度低于10纳米时有效。
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