氟桂利嗪对兔离体血管平滑肌作用的时效关系
Time course of the effect of flunarizine on rabbit isolated vascular muscle.
作者信息
Wadsworth R M, Moss J P
出版信息
Eur J Pharmacol. 1982 Nov 19;85(2):207-9. doi: 10.1016/0014-2999(82)90467-8.
PMID:7151868
Abstract
Flunarizine inhibited KCl contractions of the rabbit aorta, mesenteric artery and portal vein progressively over 3-4 h. The rate of development of block was approximately linear on a logarithmic scale and was similar for equieffective concentrations (aorta = 2.1 microM, mesenteric artery and portal vein = 0.21 microM). It is concluded that flunarizine can discriminate between calcium ion channels opened during the spike and those opened during sustained depolarization.
摘要
氟桂利嗪在3 - 4小时内逐渐抑制兔主动脉、肠系膜动脉和门静脉的氯化钾收缩。在对数尺度上，阻滞的发展速率近似呈线性，并且对于等效浓度（主动脉 = 2.1微摩尔，肠系膜动脉和门静脉 = 0.21微摩尔）是相似的。结论是，氟桂利嗪可以区分在动作电位期间开放的钙离子通道和在持续去极化期间开放的钙离子通道。
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