[Simulation of kinetics of phenazepam and its metabolite 3-hydroxyphenazepam in cat blood].

The pharmacokinetics of the tranquilizer phenazepam and its high-active metabolite 3-hydroxyphenazepam in the cat blood was studied in experiments using gas liquid chromatography and mathematic simulation. The experimental findings were computer-processed. An appreciable quantity of 3-hydroxyphenazepam was found in the blood in addition to the unchanged drug at any times after oral administration of phenazepam (2 mg/kg). Joint modelling of the kinetics of phenazepam and 2-hydroxyphenazepam within the same metabolic model allowed calculating the kinetic parameters of both the compounds. The elimination constant of the metabolite in cats was found to be twice as high on the average as compared to that of the unchanged drug.