Dubowski K M, Essary N A
J Anal Toxicol. 1982 Sep-Oct;6(5):217-21. doi: 10.1093/jat/6.5.217.
A new method was developed to apply the advantages of automated gas chromatographic headspace analysis to delayed measurement of alcohol in whole breath (W-B). End-expiratory breath and vapor-alcohol samples were collected in sealed, heated 22-mL glass vials, stored for 0-15 days, and thereafter analyzed for alcohol by automated GC with aqueous calibrators without further sample preparation. The results were compared with those of direct alcohol determinations in closely adjacent breath samples by IR absorptiometry with an Intoxilyzer. The mean difference between 389 paired-sample breath-alcohol concentrations thus determined was close to zero; the correlation coefficient for linear regression of these results plus corresponding blanks was R=0.989. The new method is practical and reliable for law enforcement, clinical, and research applications of delayed breath-alcohol analysis.
开发了一种新方法，以将自动气相色谱顶空分析的优势应用于全呼吸（W-B）中酒精的延迟测量。呼气末呼吸和蒸汽酒精样本收集在密封的、加热的22毫升玻璃小瓶中，储存0至15天，然后通过自动气相色谱仪使用水性校准剂进行酒精分析，无需进一步的样品制备。将结果与使用Intoxilyzer通过红外吸收法对紧邻呼吸样本中的酒精进行直接测定的结果进行比较。由此确定的389对配对样本呼吸酒精浓度之间的平均差异接近零；这些结果加上相应空白的线性回归相关系数为R = 0.989。这种新方法对于延迟呼吸酒精分析的执法、临床和研究应用而言既实用又可靠。
