Arias N H, Houssay A B, Pieretti S A
Acta Physiol Lat Am. 1982;32(4):261-6.
The effects of cyproterone and of tamoxifen citrate upon the hair waves were studied in normal and castrated C57 mice. Cyproterone (1 mg/day) had no effect upon the hair waves in normal male mice and produced a slight inhibition of the diffuse growth induced by their castration. Tamoxifen citrate (1 mg/day) had no effect upon the hair waves in normal female mice and produced a marked inhibition (0.2 to 1 mg/day) upon the diffuse hair growth induced by their castration. The differences between the effects of castration and the effect of these drugs can be explained in the case of cyproterone by a slight agonistic androgenic effect and in the case of tamoxifen citrate by a marked agonistic estrogenic effect upon the hair follicles in mice.
在正常和去势的C57小鼠中研究了环丙孕酮和枸橼酸他莫昔芬对毛发生长的影响。环丙孕酮（1毫克/天）对正常雄性小鼠的毛发生长没有影响，对去势诱导的弥漫性生长有轻微抑制作用。枸橼酸他莫昔芬（1毫克/天）对正常雌性小鼠的毛发生长没有影响，对去势诱导的弥漫性毛发生长有显著抑制作用（0.2至1毫克/天）。去势的影响与这些药物的影响之间的差异，在环丙孕酮的情况下可通过轻微的雄激素激动作用来解释，在枸橼酸他莫昔芬的情况下可通过对小鼠毛囊的显著雌激素激动作用来解释。
