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[急性实验性情绪应激期间家兔自主神经系统壁外神经节、工作心脏及心脏传导系统的乳酸脱氢酶同工酶谱]

[LDH isoenzyme spectrum of the extramural ganglia of the autonomic nervous system, the working heart, and cardiac conduction system of rabbits during acute experimental emotional stress].

作者信息

Petrova N V, Portugalov V V

出版信息

Biull Eksp Biol Med. 1980 Oct;90(10):497-500.

PMID:7191733
Abstract

The content of LDH isozymes was studied in extramural ganglions (superior cervical ganglion, stellate ganglion and symphathetic chain at the level of the 4th--6th thoracic segments) of the sympathetic nervous system, of the nodosal ganglion of the vagus nerve, working myocardium and conductive system of the heart of rabbits with acute experimental emotional stress provoked by simultaneous electric stimulation of the negative emotiogenic area of the hypothalamus, ventromedial nuclei, and skin. Under conditions of emotional stress no changes could be recorded in the ratio of LDH isozymic fractions in the ganglions as compared with control. No changes were found in LDH content of the working myocardium in rabbits exposed to stress. The conductive system of the heart (atrioventricular node and His' bundle) demonstrated a certain sensitivity to stress, manifesting in the increased activity of fast-moving fractions in the spectrum of LDH isozymes. The modulated electromagnetic field that exerts a protective action against an adverse effect of emotional stress produced significant shifts in LDH spectrum in the ganglions of the autonomous nervous system. No changes were detected in the spectrum of LDH isozymes in the conductive system. The results obtained suggest that the above structures of the autonomous nervous system are an important link in the bodily response to the concomitant action of the two stressors.

摘要

研究了家兔在同时电刺激下丘脑负情绪发生区、腹内侧核和皮肤所诱发的急性实验性情绪应激状态下,交感神经系统的壁外神经节(颈上神经节、星状神经节以及第4 - 6胸段水平的交感干)、迷走神经的结状神经节、工作心肌和心脏传导系统中乳酸脱氢酶(LDH)同工酶的含量。在情绪应激条件下,与对照组相比,神经节中LDH同工酶组分的比例未出现变化。应激状态下家兔工作心肌的LDH含量也未发生改变。心脏传导系统(房室结和希氏束)对应激表现出一定的敏感性,表现为LDH同工酶谱中快速移动组分的活性增加。对情绪应激的不良影响具有保护作用的调制电磁场,使自主神经系统神经节中的LDH谱发生了显著变化。在传导系统中未检测到LDH同工酶谱的变化。所得结果表明,自主神经系统的上述结构是机体对两种应激源共同作用作出反应的重要环节。

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