实验性马驹肠绞窄性肠梗阻后的内毒素血症
Endotoxemia following experimental intestinal strangulation obstruction in ponies.
作者信息
Moore J N, White N A, Berg J N, Trim C M, Garner H E
出版信息
Can J Comp Med. 1981 Jul;45(3):330-2.
Abstract
Experimental small intestinal strangulation obstruction was produced in anesthetized ponies. The limulus amoebocyte lysate test demonstrated the presence of endotoxin in the general circulation 60 and 120 minutes following restoration of mesenteric blood flow. Mucosal degeneration, with loss of villus epithelial cells, was demonstrated coincident with endotoxemia. The findings were consistent with an ischemia-mediated alteration in the intestinal barrier to endotoxin.
摘要
在麻醉的小马身上制造实验性小肠绞窄性肠梗阻。鲎试剂检测表明，肠系膜血流恢复后60分钟和120分钟时，全身循环中存在内毒素。肠黏膜变性，伴有绒毛上皮细胞丢失，与内毒素血症同时出现。这些发现与缺血介导的肠道对内毒素屏障的改变一致。
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