Ester of 6-cis-dialkylamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ol with hypotensive and other activities.
作者信息
Longobardi M, Ranise A, Bondavalli F, Mariani E, Schenone P, Lampa E, Giasi M, Paone G, Mazzeo V, Marmo E
出版信息
Farmaco Sci. 1981 Mar;36(3):225-36.
PMID:7227506
Abstract
Three series of esters of 6-cis-dialkylamino-1,3,3-trimethyl-2-oxabicyclo[2.2.2]octan-5-trans-ol (dialkylamino = pyrrolidino, piperidino, morpholino) are described. A number of these compounds showed strong hypotensive activity in rats, as well as infiltration anesthesia and antiarrhythmic activity in mice. The lowering effects on heart rate in rats are also described.
摘要
Zotero 插件