阿托品与格隆溴铵对各终末器官作用的比较。
Comparison of the effects of atropine and glycopyrrolate on various end-organs.
作者信息
Mirakhur R K, Dundee J W
出版信息
J R Soc Med. 1980 Oct;73(10):727-30.
Abstract
Atropine and glycopyrrolate (glycopyrronium bromide), a quaternary ammonium drug, were evaluated in volunteers following intramuscular administration with respect to effects on various end-organs with cholinergic innervation. Glycopyrrolate appears to be five to six times more potent than atropine in its antisialogogue effect and also exhibits a selective, though prolonged, effect on salivary secretion and sweat gland activity. It has minimal cardiovascular, ocular and central nervous system effects.
摘要
对志愿者肌内注射后，对阿托品和季铵类药物格隆溴铵（溴化格隆铵）对各种有胆碱能神经支配的终末器官的作用进行了评估。格隆溴铵的抗唾液分泌作用似乎比阿托品强五到六倍，并且对唾液分泌和汗腺活动也表现出选择性的、尽管是持久的作用。它对心血管、眼和中枢神经系统的影响极小。
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本文引用的文献
1
Atropine, scopolamine, and related compounds.
Anesthesiology. 1962 May-Jun;23:365-83. doi: 10.1097/00000542-196205000-00012.
2
Less commonly recognized actions of atropine on cardiac rhythm.
Am J Med Sci. 1959 Mar;237(3):304-18 passim. doi: 10.1097/00000441-195903000-00004.
3
Antisialogogue drugs in man; comparison of atropine, scopolamine (1-hyoscine) and 1-hyoscyamine (bellafoline).
Anaesthesia. 1957 Apr;12(2):203-14. doi: 10.1111/j.1365-2044.1957.tb03615.x.
4
The methonium.
Pharmacol Rev. 1952 Sep;4(3):219-53.
5
Glycopyrrolate as a substitute for atropine in neostigmine reversal of muscle relaxant drugs.
Can Anaesth Soc J. 1972 Jul;19(4):399-411. doi: 10.1007/BF03005964.
6
Glycopyrrolate methobromide. 1. Effect on salivary secretion.
Can Anaesth Soc J. 1974 Mar;21(2):230-41. doi: 10.1007/BF03013116.
7
Cardiac dysrhythmias in outpatient dental anaesthesia in children. The effect of prophylactic intravenous atropine.
Anaesthesia. 1972 Oct;27(4):429-35. doi: 10.1111/j.1365-2044.1972.tb08249.x.
8
Arrhythmias during halothane anaesthesia II: the influence of atropine.
Acta Anaesthesiol Scand. 1977;21(3):245-51. doi: 10.1111/j.1399-6576.1977.tb01216.x.
9
Comparative study of the effects of oral and i.m. atropine and hyoscine in volunteers.
Br J Anaesth. 1978 Jun;50(6):591-8. doi: 10.1093/bja/50.6.591.
10
Evaluation of the anticholinergic actions of glycopyrronium bromide.
Br J Clin Pharmacol. 1978 Jan;5(1):77-84. doi: 10.1111/j.1365-2125.1978.tb01601.x.
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