Park J R, Jones J G, Harkiss G D, Hazleman B L
Ann Rheum Dis. 1981 Aug;40(4):360-5. doi: 10.1136/ard.40.4.360.
Sera from patients with giant cell arteritis and/or polymyalgia rheumatica have been found to contain increased levels of circulating immune complexes (IC). Results with the polyethyleneglycol precipitation complement consumption (PEG-CC) assay have been correlated with disease activity. 44% of samples from an active untreated group (21 patients) had increased levels of ICs compared with 23% from an inactive treated group (49 patients). Further analysis of circulating ICs was performed by 125I-Clq binding, the PEG-C4 test, and 125I-conglutinin binding assays. Although we did not find a high correlation between IC levels and disease activity, isolation and analysis of the ICs may lead to further understanding of this disorder.
已发现巨细胞动脉炎和/或风湿性多肌痛患者的血清中循环免疫复合物(IC)水平升高。聚乙二醇沉淀补体消耗(PEG-CC)试验的结果与疾病活动相关。来自未治疗的活动组(21例患者)的样本中,44%的IC水平升高,而来自非活动治疗组(49例患者)的这一比例为23%。通过¹²⁵I-Clq结合、PEG-C4试验和¹²⁵I-粘连蛋白结合试验对循环IC进行了进一步分析。虽然我们未发现IC水平与疾病活动之间存在高度相关性,但对IC的分离和分析可能有助于进一步了解这种疾病。