气液色谱法对大鼠血浆中丙酰嗪的定量测定。
Quantitative determination of propildazine in rat plasma by gas-liquid chromatography.
作者信息
Ventura P, Zanol M, Visconti M, Pifferi G
出版信息
J Chromatogr. 1978 Nov 21;161:237-42. doi: 10.1016/s0021-9673(01)85232-8.
PMID:730797
Abstract
A gas-liquid chromatographic method for the evaluation of the new anti-hypertensive drug propildazine (ISF 2123) in rat plasma is described. The procedure involves separation of the drug from plasma by cation-exchange chromatography, subsequent acylation of the dried eluate with heptafluorobutyric anhydride and quantitation with electron-capture detection. Propildazine can be determined in concentrations down to ca. 0.4 microgram/ml.
摘要
本文描述了一种用于评估新型抗高血压药物丙酰嗪（ISF 2123）在大鼠血浆中含量的气液色谱法。该方法包括通过阳离子交换色谱法从血浆中分离药物，随后用七氟丁酸酐对干燥洗脱液进行酰化，并通过电子捕获检测进行定量分析。丙酰嗪的检测浓度低至约0.4微克/毫升。
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