Belhassen B, Rotmensch H H, Laniado S
Br Heart J. 1981 Dec;46(6):679-82. doi: 10.1136/hrt.46.6.679.
A 28-year-old man is described with no demonstrable organic heart disease and recurrent paroxysmal attacks of sustained ventricular tachycardia. Lignocaine and ajmaline failed to terminate the first attack but a bolus infection of verapamil succeeded. This drug was subsequently successful on six more occasions. During electrophysiological study of the eighth attack, slow intravenous administration of verapamil significantly reduced the rate of the tachycardia and prevented its subsequent reinitiation by pacing. Two mechanisms are postulated to explain both the arrhythmia and the beneficial effects of verapamil in this case.
一名28岁男性,无明显器质性心脏病,反复发生持续性室性心动过速的阵发性发作。利多卡因和阿义马林未能终止首次发作,但静脉推注维拉帕米成功。该药物随后又成功应用了6次。在对第八次发作进行电生理研究时,缓慢静脉注射维拉帕米显著降低了心动过速的速率,并通过起搏防止了其随后的再次发作。推测有两种机制来解释这种心律失常以及维拉帕米在该病例中的有益作用。