Brown C M, Collis M G
Eur J Pharmacol. 1981 Dec 3;76(2-3):275-7. doi: 10.1016/0014-2999(81)90513-6.
Adenosine (10(-4)-10(-3) M) contracted the isolated rat tail artery. This effect exhibited rapidly developing tachyphylaxis. Methysergide (10(-7) M) prevented the contractile response to adenosine and 5-hydroxytryptamine (5-HT) without affecting that to noradrenaline. Pretreatment of rats with parachlorophenylalanine (PCPA) abolished the contraction to adenosine (5 X 10(-4) M). Responses to 5-HT and noradrenaline were not significantly affected. These results indicate that the contractile response of the rat tail artery induced by adenosine is probably mediated by endogenous 5-HT.
腺苷（10⁻⁴ - 10⁻³ M）使离体大鼠尾动脉收缩。这种效应表现出快速产生的快速耐受性。麦角新碱（10⁻⁷ M）可阻止对腺苷和5-羟色胺（5-HT）的收缩反应，而不影响对去甲肾上腺素的反应。用对氯苯丙氨酸（PCPA）预处理大鼠可消除对腺苷（5×10⁻⁴ M）的收缩反应。对5-HT和去甲肾上腺素的反应未受到显著影响。这些结果表明，腺苷诱导的大鼠尾动脉收缩反应可能是由内源性5-HT介导的。
