Infectious mononucleosis initially seen as cold-induced acrocyanosis: association with auto-anti-M and anti-I antibodies.

A case of infectious mononucleosis initially seen as cold-induced acrocyanosis is discussed. Serological evaluation of the patient showed the presence of auto-anti-M and anti-I antibodies. Both the M and I antigens are normally found on RBCs. It is postulated that one or both of these antibodies were responsible for the acrocyanosis.