抗炎类固醇无法抑制大鼠多形核白细胞产生前列腺素。
Failure of anti-inflammatory steroids to inhibit prostaglandin production by rat polymorphonuclear leucocytes.
作者信息
Dray F, McCall E, Youlten L J
出版信息
Br J Pharmacol. 1980 Feb;68(2):199-205. doi: 10.1111/j.1476-5381.1980.tb10408.x.
Abstract
1 Like rabbit polymorphonuclear (PMN) leucocytes, rat peritoneal glycogen-induced PMN leucocytes produced much greater amounts of prostaglandin when incubated with killed bacteria than in the absence of phagocytosable material. 2 Rat PMN leucocytes mainly prostaglandin E2 (PGE2), in amounts up to 17 ng/10(6) cells in 90 min incubation, some 25 times the amount produced by resting cells. 3 Indomethacin and meclofenamic acid inhibited prostaglandin production by resting and phagocytosing cells, the IC50 being of the order of 10(-6) to 10(-7) M for both drugs. 4 Hydrocortisone and dexamethasone at concentrations up to 10(-4) M did not cause significant dose-related inhibition of prostaglandin production in this system. 5 It is suggested that the phagocytosing PMN leucocyte is insensitive to the action of anti-inflammatory steroids with respect to prostaglandin production.
摘要
- 与兔多形核（PMN）白细胞一样，大鼠腹腔糖原诱导的PMN白细胞在与死细菌一起孵育时比在没有可吞噬物质的情况下产生的前列腺素量要多得多。2. 大鼠PMN白细胞主要产生前列腺素E2（PGE2），在90分钟的孵育中，产生量高达17 ng/10⁶个细胞，约为静息细胞产生量的25倍。3. 吲哚美辛和甲氯芬那酸抑制静息细胞和吞噬细胞产生前列腺素，两种药物的IC50约为10⁻⁶至10⁻⁷ M。4. 在该系统中，浓度高达10⁻⁴ M的氢化可的松和地塞米松不会引起与剂量相关的显著前列腺素产生抑制。5. 有人提出，就前列腺素产生而言，吞噬性PMN白细胞对抗炎类固醇的作用不敏感。
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Studies on lysosomes. II. The effect of cortisone on the release of acid hydrolases from a large granule fraction of rabbit liver induced by an excess of vitamin A.溶酶体研究。II. 可的松对过量维生素A诱导的兔肝大颗粒组分酸性水解酶释放的影响。
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