MacDonald H M, Mulligan J C, Allen A C, Taylor P M
J Pediatr. 1980 May;96(5):898-902. doi: 10.1016/s0022-3476(80)80574-9.
The requirement of greater than one minute of positive pressure ventilation was prospectively used to identify infants suffering from asphyxia at birth in 38,405 consecutive deliveries. Multivariate analysis of high-risk factors associated with increased risk of asphyxia showed the prematurity was the most significant predictor of asphyxia. Asphyxia occurred in 62.3% of infants less than 27 weeks' gestation and decreased to 0.4% in infants greater than 38 weeks' gestation. Presence of asphyxia was associated with significant increase in neonatal mortality of infants greater than 36 weeks' gestation. Of the asphyxiated neonates, growth retardation, hypothermia, hyaline membrane disease, and seizures were significantly associated with an increased risk of death.
在38405例连续分娩中，前瞻性地采用大于1分钟的正压通气需求来识别出生时窒息的婴儿。对与窒息风险增加相关的高危因素进行多变量分析显示，早产是窒息最显著的预测因素。孕周小于27周的婴儿中62.3%发生窒息，而孕周大于38周的婴儿中窒息发生率降至0.4%。孕周大于36周的婴儿发生窒息与新生儿死亡率显著增加相关。在窒息新生儿中，生长发育迟缓、体温过低、透明膜病和惊厥与死亡风险增加显著相关。
