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4-羟基-5-氧代-4,5-二氢苯并(a)芘，苯并(a)芘的一种新代谢产物。

4-Hydroxy-5-oxo-4,5-dihydrobenzo(a)pyrene, a new metabolite of benzo(a)pyrene.

作者信息

Lhoëst G

出版信息

Eur J Drug Metab Pharmacokinet. 1980;5(1):41-3. doi: 10.1007/BF03189442.

DOI:10.1007/BF03189442
PMID:7389750
Abstract

The detection and the isolation in phenobarbital-induced rat liver microsomal incubation systems of a new metabolite of benzo(a)pyrene are described. The structure of this metabolite and the way in which it is formed are described.

摘要

本文描述了在苯巴比妥诱导的大鼠肝微粒体孵育系统中对苯并(a)芘一种新代谢物的检测与分离。还描述了该代谢物的结构及其形成方式。

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1
4-Hydroxy-5-oxo-4,5-dihydrobenzo(a)pyrene, a new metabolite of benzo(a)pyrene.4-羟基-5-氧代-4,5-二氢苯并(a)芘，苯并(a)芘的一种新代谢产物。
Eur J Drug Metab Pharmacokinet. 1980;5(1):41-3. doi: 10.1007/BF03189442.
2
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Benzo[e]pyrene metabolism in rat liver microsomes: dependence of the metabolite profile on the pretreatment of rats with various monooxygenase inducers.
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Pyrrolizidine alkaloid-induced alterations in benzo[alpha]pyrene metabolism and binding of benzo[alpha]pyrene metabolites to deoxyribonucleic acid.
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The metabolism of antifertility steroids. The in virto metabolism of chlormadinone acetate.抗生育甾体的代谢。醋酸氯地孕酮的体外代谢。
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引用本文的文献

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Isolation and mass spectrometric identification of gitoxin metabolites excreted in bile.胆汁中排泄的吉他洛辛代谢物的分离与质谱鉴定。
Eur J Drug Metab Pharmacokinet. 1982;7(2):111-7. doi: 10.1007/BF03188727.

本文引用的文献

1
The metabolism of methylated aminoazo dyes. IV. Dietary factors enhancing demethylation in vitro.甲基化氨基偶氮染料的代谢。IV. 体外增强去甲基化作用的膳食因素。
J Biol Chem. 1954 Jul;209(1):211-22.
2
Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis.多环芳烃代谢与致癌过程中的环氧化物
Adv Cancer Res. 1974;20:165-274. doi: 10.1016/s0065-230x(08)60111-6.
3
Analytical study of microsomes and isolated subcellular membranes from rat liver. II. Preparation and composition of the microsomal fraction.大鼠肝脏微粒体和分离的亚细胞膜的分析研究。II. 微粒体部分的制备与组成
J Cell Biol. 1974 Apr;61(1):201-12. doi: 10.1083/jcb.61.1.201.
4
"K-region" oxides and related oxidized metabolites of carcinogenic aromatic hydrocarbons.致癌芳烃的“K区域”氧化物及相关氧化代谢物。
J Am Chem Soc. 1975 Jun 11;97(12):3468-79. doi: 10.1021/ja00845a032.
5
Chemical carcinogenesis.化学致癌作用
Annu Rev Biochem. 1975;44:79-121. doi: 10.1146/annurev.bi.44.070175.000455.
6
Benzo[a]pyrene carcinogenesis: a biochemical selection mechanism.苯并[a]芘致癌作用：一种生化选择机制。
J Toxicol Environ Health. 1977 Jul;2(6):1245-58. doi: 10.1080/15287397709529527.