Aminoalkanesulfonic acids IV:Synthesis of mitodepressive N-nitrosoaminoalkanesulfonic acids.

Sodium aminoalkanesulfonates were synthesized from substituted amines and aldehyde sodium bisulfites at 40-60 degrees. Nitrosation yielded the corresponding N-nitroso derivatives. Mitodepressive activity on cresse (Lepidium sativum L.) was determined, and all compounds examined possessed growth inhibition activity. The N-nitroso derivatives were slightly less active but also showed less toxicity than the parent aminoalkanesulfonic acids.