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三氯生:人体接触性皮炎潜在可能性评估

Triclocarban: evaluation of contact dermatitis potential in man.

作者信息

Maibach H, Bandmann H J, Calnan C D, Cronin E, Fregert S, Hjorth N, Magnusson B, Malten K E, Meneghini C L, Pirilä V, Wilkinson D S, Johannsen F R

出版信息

Contact Dermatitis. 1978 Oct;4(5):283-8. doi: 10.1111/j.1600-0536.1978.tb04559.x.

Abstract

Triclocarban was subjected to a profiling of its dermatitis producing potential including irritancy (21-day cumulative irritancy potential and application to 213 normal controls), phototoxicity (method of Marzulli), predictive contact sensitization (modified Draize method), predictive phototesting and battery screening in 2200 dermatitis patients, in an effort to define its relative dermatitis potential. The allergic contact dermatitis potential of triclocarban following bar soap use appears minimal.

摘要

对三氯生进行了其产生皮炎可能性的分析,包括刺激性(21天累积刺激可能性及应用于213名正常对照者)、光毒性(采用马祖利方法)、预测性接触致敏(改良的德莱兹方法)、预测性光测试以及对2200名皮炎患者进行组套筛选,以确定其相对的皮炎可能性。使用肥皂后三氯生引发过敏性接触性皮炎的可能性似乎极小。

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