胃肠道癌患者的迟发型皮肤超敏反应与外周血淋巴细胞计数

Delayed cutaneous hypersensitivity ad peripheral blood lymphocyte counts in gastrointestinal cancer.

作者信息

Gupta S, Seth S K, Udupa K N, Sen P C

出版信息

Ann Acad Med Singap. 1980 Jan;9(1):71-6.

Abstract

Cell-mediated immune responses as expressed by delayed cutaneous hypersensitivity (DCH) reactions to specific recall antigens (PPD and BCG) and non-specific contact antigen (DNCB), and peripheral blood lymphocyte counts were studied in 60 patients of gastrointestinal cancer and 20 control subjects. The pattern of these immune responses in gastrointestinal cancer was significantly different from tumour-free control subjects of comparable age and sex distribution and apparently indicates a depressed immunologic function in cancer patients. Our study suggests that DNCB skin testing and peripheral blood lymphocyte counts are relatively simple and reliable investigations for predicting the advanced stage of gastrointestinal cancer (and BBY implication prognosis).

摘要

我们对60例胃肠道癌患者和20例对照者进行了研究，观察了以对特异性回忆抗原（结核菌素纯蛋白衍生物和卡介苗）和非特异性接触抗原（二硝基氯苯）的迟发性皮肤超敏反应（DCH）所表现出的细胞介导免疫反应，以及外周血淋巴细胞计数。胃肠道癌患者的这些免疫反应模式与年龄和性别分布相当的无肿瘤对照者显著不同，这显然表明癌症患者的免疫功能受到抑制。我们的研究表明，二硝基氯苯皮肤试验和外周血淋巴细胞计数是预测胃肠道癌晚期（以及预后）相对简单且可靠的检查方法。