高剂量奈替米星和妥布霉素对大鼠的肾毒性比较
Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats.
作者信息
Parker R A, Gilbert D N, Houghton D C, Porter G A, Bennett W M
出版信息
Antimicrob Agents Chemother. 1980 Aug;18(2):346-8. doi: 10.1128/AAC.18.2.346.
Abstract
The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.
摘要
在Fischer大鼠中比较了奈替米星和妥布霉素每日剂量为180mg/kg、给药长达14天的肾毒性潜力。在此剂量下，妥布霉素导致死亡以及肾脏结构和功能的显著变化；奈替米星引起的肾毒性最小。
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