Stchepinsky O, Danchin N, Selton-Suty C, Hoen B, Feldmann L, Juillière Y, Amrein D, Villemot J P, Mathieu P, Canton P
Service de cardiologie A, CHU Nancy-Brabois, Vandoeuvre-lès-Nancy.
Arch Mal Coeur Vaiss. 1995 Jul;88(7):993-8.
Annular abscess is a not uncommon but serious complication of aortic valve endocarditis. The aim of this retrospective study was to evaluate the prognosis of aortic valve endocarditis with and without annular abscess. Between January 1981 and 1989, 122 consecutive cases of aortic endocarditis fulfilling the diagnostic criteria of Duke University were admitted to hospital. Group I included 40 cases with aortic ring abscess confirmed at surgery, in 35 patients; group II comprised 43 cases of operated aortic valve endocarditis without annular abscess in 41 patients and group III comprised 38 cases of aortic valve endocarditis treated medically without echocardiographic or angiographic signs of annular abscess in 36 patients. The patients in group III were significantly older than those in group I (57 +/- 14 years vs 44 +/- 17 years; p < 0.001). From the clinical point of view, endocarditis of prosthetic valves was slightly more common, but without reaching statistical significance, in group I, but the abscess was associated with more severe cardiac failure. Systemic embolism, atrioventricular block and pericardial effusion were equally common in the three groups. On the other hand, endocarditis with annular abscess was more often the result of infection with streptococci A, B, C or pneumoniae, than forms without abscess (22.5% vs 5% and 3% respectively in the 3 groups; p < 0.05). Of the patients treated surgically, destructive lesions of the valves were more common in cases of abscess (57.5% vs 35%; p < 0.05): the hospital mortality was higher in cases of abscess (17.5% vs 7%).(ABSTRACT TRUNCATED AT 250 WORDS)
瓣周脓肿是主动脉瓣心内膜炎一种虽不罕见但严重的并发症。本回顾性研究旨在评估伴或不伴瓣周脓肿的主动脉瓣心内膜炎的预后。1981年1月至1989年期间,122例符合杜克大学诊断标准的连续性主动脉心内膜炎病例入院。第一组包括40例手术证实有主动脉环脓肿的病例,其中35例患者;第二组包括43例接受手术治疗的主动脉瓣心内膜炎病例,41例患者无瓣周脓肿;第三组包括38例接受药物治疗的主动脉瓣心内膜炎病例,36例患者无超声心动图或血管造影显示的瓣周脓肿迹象。第三组患者比第一组患者年龄显著更大(57±14岁对44±17岁;p<0.001)。从临床角度看,人工瓣膜心内膜炎在第一组中略更常见,但未达到统计学意义,但脓肿与更严重的心力衰竭相关。三组中全身栓塞、房室传导阻滞和心包积液同样常见。另一方面,与无脓肿的形式相比,伴有瓣周脓肿的心内膜炎更常由A、B、C组链球菌或肺炎链球菌感染引起(三组分别为22.5%对5%和3%;p<0.05)。在接受手术治疗的患者中,瓣膜破坏性病变在有脓肿的病例中更常见(57.5%对35%;p<0.05):有脓肿病例的医院死亡率更高(17.5%对7%)。(摘要截短于250字)