异位促肾上腺皮质激素分泌型支气管类癌肿瘤中的内皮素

Endothelin in ectopic ACTH-secreting bronchial carcinoid tumors.

作者信息

Takahashi K, Satoh F, Murakami O, Totsune K, Sone M, Itoi K, Ohneda M, Mouri T

机构信息

Second Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan.

出版信息

J Cardiovasc Pharmacol. 1993;22 Suppl 8:S288-90. doi: 10.1097/00005344-199322008-00075.

DOI:10.1097/00005344-199322008-00075

PMID:7509967

Abstract

The presence of immunoreactive endothelin (ir-ET) in the tumor tissues of two cases of ectopic ACTH-secreting bronchial carcinoid tumors was studied by radioimmunoassay. The cross-reaction with big ET-1, ET-2, and ET-3 was 5%, 6%, and 6%, respectively. Tumor tissue ir-ET concentrations in two ectopic ACTH-secreting bronchial carcinoid tumors were 920 and 3,370 fmol/g wet weight, which were much higher than those in pheochromocytomas (146 +/- 70 fmol/g wet weight; n = 12, mean +/- SD), adrenocortical tumors (115 +/- 105 fmol/g wet weight, n = 14), and normal parts of adrenal glands (82 +/- 31 fmol/g wet weight, n = 12). High-performance liquid chromatography of the tumor tissue extract showed that the ir-ET was mainly eluted in the position of ET-1. Plasma levels of ir-ET in these two cases were not elevated (1.2 and 1.7 pmol/L). The findings of the present study suggest that ET-1 has local pathophysiologic roles in the tumor tissues of ectopic ACTH-secreting bronchial carcinoid tumors.

摘要

采用放射免疫分析法研究了2例异位促肾上腺皮质激素（ACTH）分泌型支气管类癌肿瘤组织中免疫反应性内皮素（ir-ET）的存在情况。与大内皮素-1（big ET-1）、内皮素-2（ET-2）和内皮素-3（ET-3）的交叉反应率分别为5%、6%和6%。2例异位ACTH分泌型支气管类癌肿瘤组织中的ir-ET浓度分别为920和3370 fmol/g湿重，远高于嗜铬细胞瘤（146±70 fmol/g湿重；n = 12，均值±标准差）、肾上腺皮质肿瘤（115±105 fmol/g湿重，n = 14）以及肾上腺正常组织（82±31 fmol/g湿重，n = 12）。肿瘤组织提取物的高效液相色谱分析表明，ir-ET主要在ET-1的位置洗脱。这2例患者的血浆ir-ET水平未升高（分别为1.2和1.7 pmol/L）。本研究结果提示，ET-1在异位ACTH分泌型支气管类癌肿瘤组织中具有局部病理生理作用。