大鼠肠道中编码P物质的前速激肽原信使核糖核酸的第四种同工型。

Fourth isoform of preprotachykinin messenger RNA encoding for substance P in the rat intestine.

作者信息

Khan I, Collins S M

机构信息

Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

出版信息

Biochem Biophys Res Commun. 1994 Jul 29;202(2):796-802. doi: 10.1006/bbrc.1994.2000.

DOI:10.1006/bbrc.1994.2000

PMID:7519424

Abstract

Three different isoforms of preprotachykinin mRNA (PPT mRNA) encode for substance P and related neuropeptides (1). Here we report a fourth isoform of PPT mRNA which is generated by alternative exclusion of exon-7 and exon-6 from the PPT mRNA. It was present mainly in ileal smooth muscle and mucosa, colon, heart and brain and low level of this mRNA was detected in the jejunal smooth muscle and mucosa. This was not detected in the kidney or uterus. The level of this PPT mRNA was enhanced significantly by 60% during colitis in rat induced by trinitro benzene sulphonic acid.

摘要

前速激肽原mRNA（PPT mRNA）的三种不同同工型编码P物质及相关神经肽（1）。在此我们报告PPT mRNA的第四种同工型，它是通过从PPT mRNA中选择性排除外显子7和外显子6产生的。它主要存在于回肠平滑肌和黏膜、结肠、心脏和大脑中，在空肠平滑肌和黏膜中检测到该mRNA的水平较低。在肾脏或子宫中未检测到。在三硝基苯磺酸诱导的大鼠结肠炎期间，这种PPT mRNA的水平显著提高了60%。