Fungal metabolites. XVII. Synthesis and NMR study of ion channel-forming peptides, trichosporin B-VIa and its derivative.
作者信息
Nagaoka Y, Iida A, Fujita T
机构信息
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1258-63. doi: 10.1248/cpb.42.1258.
PMID:7520842
Abstract
A membrane-modifying peptide antibiotic, trichosporin B-VIa, having catecholamine secretion-inducing activity on bovine adrenal chromaffin cells has been synthesized. Aib14-Trichosporin B-VIa, in which Pro14 was replaced by Aib, has also been synthesized to modify the secondary structure of trichosporin B-VIa. Sequence-specific 1H-NMR assignments of both peptides in methanol were achieved by using two-dimensional NMR techniques.
摘要
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