磷酸肌醇3激酶抑制剂渥曼青霉素可抑制CD28介导的T细胞共刺激。 - Suppr

The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.

作者信息

Wilson A, Sansom D, Parry R, Westwick J, Ward S

机构信息

School of Pharmacy and Pharmacology, University of Bath.

出版信息

Biochem Soc Trans. 1995 May;23(2):282S. doi: 10.1042/bst023282s.

DOI:10.1042/bst023282s

PMID:7545611

Abstract

摘要

相似文献

The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.

Biochem Soc Trans. 1995 May;23(2):282S. doi: 10.1042/bst023282s.

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Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.

Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8808-12. doi: 10.1073/pnas.92.19.8808.

Phorbol esters modulate the coupling of the T cell costimulatory molecule CD28 to phosphatidylinositol 3-kinase.

Biochem Soc Trans. 1997 May;25(2):305S. doi: 10.1042/bst025305s.

Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells.

Biochem Biophys Res Commun. 1996 Jun 5;223(1):80-4. doi: 10.1006/bbrc.1996.0849.

Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin.

Eur J Immunol. 1995 Feb;25(2):533-7. doi: 10.1002/eji.1830250234.

Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction.

Mol Immunol. 1997 Feb;34(3):221-6. doi: 10.1016/s0161-5890(97)00027-8.

CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.

Mol Cell Biol. 1995 Dec;15(12):6820-8. doi: 10.1128/MCB.15.12.6820.

PI 3-kinase: a pivotal pathway in T-cell activation?

Immunol Today. 1996 Apr;17(4):187-97. doi: 10.1016/0167-5699(96)80618-9.

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

EMBO J. 1996 Oct 1;15(19):5256-67.

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The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.

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