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[自膨式金属内支架在上消化道狭窄性肿瘤姑息治疗中的应用。82例植入三种支架类型的经验比较]

[Self-expanding metal endoprosthesis in palliation of stenosing tumors of the upper gastrointestinal tract. Comparison of experience with three stent types in 82 implantations].

作者信息

Ell C, May A, Hahn E G

机构信息

Medizinische Klinik I mit Poliklinik, Universität Erlangen-Nürnberg.

出版信息

Dtsch Med Wochenschr. 1995 Oct 6;120(40):1343-8. doi: 10.1055/s-2008-1055483.

Abstract

INTRODUCTION AND AIM OF STUDY

As there are no reports of studies comparing different self-expanding metal stent types the results obtained with three stent types in 73 patients (58 men, 15 women; mean age 65 [43-90] years who had a total of 82 implantation were analysed.

PATIENTS AND METHODS

31 Wallstents were implanted in 23 patients, 31 Ultraflex stents (all without covering) in 30 patients, and 20 Gianturco-Z stents (with covering) in 20 patients. The three groups of patients did not differ significantly with respect to degree of dysphagia, frequency of previous treatment, length of stenosis by tumour, tumour localization and histological tumour type. Six patients, treated with the Gianturco-Z stent, had an tracheo-oesophageal fistula.

RESULTS

All 82 implantations were technically successful. Complete occlusion was achieved in all patients with fistulas, as proven radiologically. Serious early complications, namely stent migration, occurred in two patients (2.4%). The degree of dysphagia improved equally in all three groups (Wallstent, from 2.0 to 0.7; Ultraflex from 2.2 to 0.9, Gianturco-Z from 2.1 to 0.5 (not significant). The median follow-up time differed: 89 days for the Wallstent group, 129 for the Ultraflex group and 77 days for the Gianturco-Z group. Tumour ingrowth was the main problem with the non-covered stents. Accordingly, there were 43% reinterventions with the Wallstent, 37% with the Ultraflex and 20% with the Gianturco-Z stents.

CONCLUSIONS

Self-expanding metal stents improve palliative treatment of stenosing tumours of the oesophagus and cardia, particularly in view of the low complication rate (< 3%) in the early postimplantation phase. But technical improvements are needed to reduce the number of reinterventions for restenosis in the follow-up period.

摘要

研究的引言和目的

由于尚无比较不同自膨式金属支架类型的研究报道,因此对73例患者(58例男性,15例女性;平均年龄65[43 - 90]岁)共82次植入三种支架类型所获得的结果进行了分析。

患者和方法

23例患者植入了31个Wallstent支架,30例患者植入了31个Ultraflex支架(均无覆膜),20例患者植入了20个Gianturco-Z支架(有覆膜)。三组患者在吞咽困难程度、既往治疗频率、肿瘤所致狭窄长度、肿瘤定位和组织学肿瘤类型方面无显著差异。接受Gianturco-Z支架治疗的6例患者存在气管食管瘘。

结果

所有82次植入在技术上均获成功。经放射学证实,所有瘘管患者均实现了完全闭塞。发生了两例严重的早期并发症,即支架移位(2.4%)。三组患者的吞咽困难程度均有同等程度改善(Wallstent支架组从2.0降至0.7;Ultraflex支架组从2.2降至0.9;Gianturco-Z支架组从2.1降至0.5(无显著差异)。中位随访时间有所不同:Wallstent支架组为89天,Ultraflex支架组为129天,Gianturco-Z支架组为77天。肿瘤向内生长是无覆膜支架的主要问题。因此,Wallstent支架的再次干预率为43%,Ultraflex支架为37%,Gianturco-Z支架为20%。

结论

自膨式金属支架改善了食管和贲门狭窄性肿瘤的姑息治疗,特别是考虑到植入后早期并发症发生率较低(<3%)。但需要技术改进以减少随访期内再狭窄的再次干预次数。

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