Lewinsohn P M, Gotlib I H, Seeley J R
Oregon Research Institute, Eugene 97403-1983, USA.
J Am Acad Child Adolesc Psychiatry. 1995 Sep;34(9):1221-9. doi: 10.1097/00004583-199509000-00021.
To determine the specificity to major depressive disorder (MDD) of a wide array of psychosocial risk factors in older adolescents (aged 14 through 18 years).
Diagnostic and psychosocial assessments were conducted with 1,507 randomly selected high school students at T1 and after approximately 1 year (T2). Three diagnostic groups were compared: those who had an episode of MDD during that year (n = 90), those who had an episode of substance use disorder during that year (SUD) (n = 42), and a control group with no disorder (n = 1,189).
Risk factors specific to MDD were stress (minor and major events), emotional reliance, physical symptoms and disease, history of suicide attempt, and a past episode of depression or anxiety disorder. Risk factors specific to SUD were tobacco use, academic difficulties, and a past episode of SUD. Risk factors that were shared were current depression symptoms, internalizing and externalizing behavior problems, coping skills, interpersonal conflict with parents, and dissatisfaction with grades.
By determining the number of risk factors for MDD, for SUD, or those that are general to both disorders, clinicians can make informed predictions concerning the probable future onset of a full-fledged episode of MDD and/or SUD in individual cases. The results of this study allow for the identification of adolescents who are at elevated risk for MDD and SUD. The results also have implications for the design of interventions aimed at preventing the occurrence of these disorders. Such interventions should target change on risk factors of the type identified in this study.
确定一系列心理社会风险因素对年龄较大的青少年(14至18岁)重度抑郁症(MDD)的特异性。
对1507名随机选取的高中生在T1时以及大约1年后(T2)进行诊断和心理社会评估。比较了三个诊断组:当年患有MDD发作的(n = 90)、当年患有物质使用障碍发作的(SUD)(n = 42)以及无疾病的对照组(n = 1189)。
MDD特有的风险因素包括压力(轻微和重大事件)、情感依赖、身体症状和疾病、自杀未遂史以及过去的抑郁或焦虑症发作。SUD特有的风险因素包括吸烟、学业困难以及过去的SUD发作。共同的风险因素包括当前的抑郁症状、内化和外化行为问题、应对技能、与父母的人际冲突以及对成绩的不满。
通过确定MDD、SUD的风险因素数量或两种疾病共有的风险因素数量,临床医生可以对个别病例中可能未来出现的全面MDD和/或SUD发作做出明智的预测。本研究结果有助于识别MDD和SUD风险较高的青少年。结果还对旨在预防这些疾病发生的干预措施设计具有启示意义。此类干预措施应针对本研究中确定的风险因素类型进行改变。