由核受体共抑制因子介导的甲状腺激素受体的非配体依赖性抑制作用。

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.

作者信息

Hörlein A J, Näär A M, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass C K

机构信息

Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0648, USA.

出版信息

Nature. 1995 Oct 5;377(6548):397-404. doi: 10.1038/377397a0.

DOI:10.1038/377397a0

PMID:7566114

Abstract

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

摘要

甲状腺激素受体和视黄酸受体通过作为基因表达的激活剂和抑制剂来发挥其调节功能。已鉴定出一种相对分子质量为270K的核受体共抑制因子（N-CoR），它介导这些受体对基因转录的非配体依赖性抑制，这表明甲状腺激素受体和视黄酸受体的抑制分子机制类似于酵母和果蝇中依赖共抑制因子的转录抑制机制。