咪唑烷-2,4-二酮和吡咯烷-2,5-二酮II的碱性酰胺衍生物的合成及其抗心律失常特性。
Synthesis and antiarrhythmic properties of basic amide derivatives of imidazolidine-2,4-dione and pyrrolidine-2,5-dione II.
作者信息
Kieć-Kononowicz K, Byrtus H, Zejc A, Filipek B, Chevallet P
机构信息
Zakład Technologii Chemicznej, Srodkow Leczniczych Collegium Medicum, Uniwersytet Jagiellonski, Kraków, Polska.
出版信息
Farmaco. 1995 May;50(5):355-60.
PMID:7626171
Abstract
Basic amide derivatives of imidazolidine-2,4-dione and pyrrolidine-2,5-dione were synthesized as potential antiarrhythmic agents. Some of them have shown antiarrhythmic activity in the chloroform, barium chloride or adrenaline induced arrhythmia.
摘要
合成了咪唑烷 - 2,4 - 二酮和吡咯烷 - 2,5 - 二酮的碱性酰胺衍生物作为潜在的抗心律失常药物。其中一些在氯仿、氯化钡或肾上腺素诱导的心律失常中显示出抗心律失常活性。
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