Banks P M, Witrak G A, Conn D L
Mayo Clin Proc. 1979 Feb;54(2):104-8.
A retrospective review was undertaken to ascertain whether there are distinctive histopathologic features of the lymphoid neoplasms that occur in patients with previous connective tissue disease. Of 29 patients studied, 12 had malignant lymphoma with diffuse large-cell cytomorphology. Only 1 of these 12 had an immunoblastic cell type. The remaining 17 patients had neoplasia of a widely diverse nature. Six had lymphocytic lymphoma (one nodular poorly differentiated, three diffuse poorly differentiated, and three diffuse well differentiated), two had Hodgkin's disease, three had plasma cell myeloma, and six had chronic lymphocytic leukemia. Data fail to confirm a relationship between lymphoid proliferations with immunoblastic morphology and connective tissue diseases.
进行了一项回顾性研究，以确定既往有结缔组织病的患者发生的淋巴样肿瘤是否具有独特的组织病理学特征。在研究的29例患者中，12例患有弥漫性大细胞细胞形态学的恶性淋巴瘤。这12例中只有1例为免疫母细胞型。其余17例患者患有性质广泛多样的肿瘤。6例患有淋巴细胞性淋巴瘤（1例结节性低分化、3例弥漫性低分化和3例弥漫性高分化），2例患有霍奇金病，3例患有浆细胞骨髓瘤，6例患有慢性淋巴细胞白血病。数据未能证实具有免疫母细胞形态的淋巴样增殖与结缔组织病之间存在关联。
