Hajarizadeh H, Rohrer M J, Herrmann J B, Cutler B S
Division of Vascular Surgery, University of Massachusetts Medical Center, Worcester 01655, USA.
Am J Surg. 1995 Aug;170(2):223-6. doi: 10.1016/s0002-9610(99)80291-8.
Acute renal failure is common after repair of ruptured abdominal aortic aneurysm. Early dialysis has recently been advocated to reduce the mortality associated with multiorgan failure, but hemodialysis (HD) is not well-tolerated in critically ill patients because of hemodynamic instability and risk of bleeding from anticoagulation therapy. Peritoneal dialysis (PD) has the advantage in that it causes minimal cardiopulmonary instability and does not require anticoagulation. The presence of a freshly-closed abdominal wound and an aortic graft, however, have previously been considered to be contraindications to PD.
Peritoneal dialysis catheters were placed in 69 of the 105 patients who underwent grafting for a ruptured abdominal aortic aneurysm between 1982 and 1993. Criteria for placement included shock, perioperative oliguria, and preoperative renal insufficiency. All charts were reviewed retrospectively to evaluate the safety and efficacy of placing PD catheters and initiating early dialysis in patients at risk for developing acute renal failure.
Acute tubular necrosis developed in 31 patients, 19 of whom required dialysis. Peritoneal dialysis alone provided effective dialysis in 8 patients, and it was combined with hemofiltration and/or HD in 9 additional patients for an overall efficacy of 58%. The peritoneal catheter also facilitated the early diagnosis of peritonitis due to colon ischemia in 5 patients, and was helpful in diagnosing intra-abdominal hemorrhage in 4 others. Bacterial peritonitis occurred in 3 (17%) patients undergoing PD with no cause noted for the infection diagnosing other than use of the PD catheter. A single aortic graft infection was diagnosed 4.2 years postoperatively with an enteric organism in a patient with recurrent diverticulitis. Two patients with peritoneal catheters developed abdominal wound dehiscence, but neither had undergone PD (P > 0.2). In a multivariate analysis, placement of a PD catheter did not affect survival.
Placement of a PD catheter at the time of resection of a ruptured abdominal aortic aneurysm in patients at risk for development of acute renal failure is without significant complications and can facilitate early and effective dialysis. The peritoneal dialysis catheter may also be useful in making an early diagnosis of intraperitoneal bleeding and infection.
腹主动脉瘤破裂修复术后急性肾衰竭很常见。近来有人主张早期透析以降低与多器官功能衰竭相关的死亡率,但由于血流动力学不稳定和抗凝治疗导致出血的风险,重症患者对血液透析(HD)耐受性不佳。腹膜透析(PD)的优势在于其引起的心肺不稳定最小且无需抗凝。然而,新近缝合的腹部伤口和主动脉移植物的存在以前被认为是腹膜透析的禁忌证。
在1982年至1993年间接受腹主动脉瘤破裂修补术的105例患者中,69例放置了腹膜透析导管。放置标准包括休克、围手术期少尿和术前肾功能不全。回顾所有病历以评估在有发生急性肾衰竭风险的患者中放置腹膜透析导管及开始早期透析的安全性和有效性。
31例患者发生急性肾小管坏死,其中19例需要透析。单纯腹膜透析使8例患者获得有效透析,另外9例患者腹膜透析联合血液滤过和/或血液透析,总有效率为58%。腹膜导管还促成了5例因结肠缺血所致腹膜炎的早期诊断,并有助于另外4例患者腹腔内出血的诊断。3例(占17%)接受腹膜透析的患者发生细菌性腹膜炎,除使用腹膜透析导管外未发现其他感染原因。1例复发性憩室炎患者术后4.2年被诊断为单一主动脉移植物感染,病原体为肠道细菌。2例放置腹膜导管的患者发生腹部伤口裂开,但均未进行腹膜透析(P>0.2)。多因素分析显示,放置腹膜透析导管不影响生存率。
在有发生急性肾衰竭风险的腹主动脉瘤破裂切除患者中放置腹膜透析导管无明显并发症,且可促成早期有效透析。腹膜透析导管也可能有助于腹腔内出血和感染的早期诊断。