Kurzer M S, Lampe J W, Martini M C, Adlercreutz H
Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.
Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):353-8.
Lignans and isoflavonoids are diphenolic compounds found in plant foods, particularly whole grains and legumes. They have been shown to have anticarcinogenic properties in animal and cell studies, and have been associated with reduced cancer risk in epidemiological studies. In order to perform further epidemiological and metabolic studies on these compounds, it is necessary to be able to monitor concentrations in biological samples. In this study, we examined the effects of consumption of flaxseed, a concentrated source of lignans, on fecal lignan excretion and evaluated the effect of high lignan consumption on fecal excretion of isoflavonoids. Thirteen women were studied for two diet periods of three menstrual cycles each in a cross-over design. During the control period, they consumed their usual diets; during the treatment period they consumed their usual diets supplemented with 10 g/day ground flaxseed. Feces were collected on days 7-11 of the last menstrual cycle in each diet period. Five-day fecal composites were analyzed for lignans and isoflavonoids by isotope dilution gas chromatography-mass spectrometry. Fecal excretion of the lignans enterodiol, enterolactone, and matairesinol increased significantly with flax consumption, from 80.0 +/- 80.0 (SD) to 2560 +/- 3100; 640 +/- 480 to 10,300 +/- 7580; and 7.33 +/- 10.0 to 11.9 +/- 8.06 nmol/day, respectively. There were no differences in fecal excretion of the isoflavonoids, daidzein, equol, genistein, and O-demethylangolensin.
木脂素和异黄酮是在植物性食物中发现的双酚类化合物，特别是在全谷物和豆类中。在动物和细胞研究中，它们已被证明具有抗癌特性，并且在流行病学研究中与降低癌症风险有关。为了对这些化合物进行进一步的流行病学和代谢研究，有必要能够监测生物样本中的浓度。在本研究中，我们研究了食用富含木脂素的亚麻籽对粪便木脂素排泄的影响，并评估了高木脂素摄入量对异黄酮粪便排泄的影响。采用交叉设计，对13名女性进行了两个饮食期的研究，每个饮食期为三个月经周期。在对照期，她们食用平常的饮食；在治疗期，她们食用平常饮食并补充每天10克磨碎的亚麻籽。在每个饮食期的最后一个月经周期的第7 - 11天收集粪便。通过同位素稀释气相色谱 - 质谱法分析5天的粪便混合物中的木脂素和异黄酮。食用亚麻籽后，木脂素肠二醇、肠内酯和matairesinol的粪便排泄量显著增加，分别从80.0±80.0（标准差）增加到2560±3100；640±480增加到10300±7580；以及7.33±10.0增加到11.9±8.06纳摩尔/天。异黄酮黄豆苷元、雌马酚、染料木黄酮和O - 去甲基安哥拉紫檀素的粪便排泄量没有差异。
