Hennis B C, Boomsma D I, Fijnvandraat K, Gevers Leuven J A, Peters M, Kluft C
Gaubius Laboratory, TNO-PG, Leiden, The Netherlands.
Thromb Haemost. 1995 Mar;73(3):484-7.
Plasma levels of histidine-rich glycoprotein (HRG) were investigated in three groups of women receiving a different dose of estrogens. First, the effect of low-dose estrogen was studied in a group of 83 postmenopausal women who were treated with 0.625 mg conjugated estrogens (CE). No significant change from baseline levels was found at the end of cycle 3 and cycle 13. Secondly, in 15 mothers and 23 daughters using oral contraceptives (OC) containing 30-50 micrograms ethinyl estradiol (EE) daily the mean HRG level was 14% and 24% lower than in a group of 144 mothers and 134 daughters not taking oral contraceptives, respectively (p < 0.05). Finally, in 11 excessively tall prepuberal girls who received 300 micrograms EE daily to reduce their final height the mean plasma HRG levels were decreased by 68% (p < 0.005). The effect of progestogens administered during low-dose and high-dose estrogen therapy appeared to be minor. The results from these three studies indicate that estrogens reduce plasma HRG levels in a dose-dependent way.
对三组接受不同剂量雌激素治疗的女性的富含组氨酸糖蛋白（HRG）血浆水平进行了研究。首先，在一组83名接受0.625毫克共轭雌激素（CE）治疗的绝经后女性中研究了低剂量雌激素的作用。在第3周期和第13周期结束时，未发现与基线水平有显著变化。其次，在15名母亲和23名女儿每天使用含30 - 50微克炔雌醇（EE）的口服避孕药（OC）的人群中，平均HRG水平分别比144名母亲和134名未服用口服避孕药的女儿组成的对照组低14%和24%（p < 0.05）。最后，在11名身材过高的青春期前女孩中，她们每天接受300微克EE以降低最终身高，平均血浆HRG水平降低了68%（p < 0.005）。在低剂量和高剂量雌激素治疗期间给予孕激素的影响似乎较小。这三项研究的结果表明，雌激素以剂量依赖的方式降低血浆HRG水平。
