抗体对T细胞表位加工的抑制作用。
Suppressive effect of antibody on processing of T cell epitopes.
作者信息
Watts C, Lanzavecchia A
机构信息
Department of Biochemistry, University of Dundee, United Kingdom.
出版信息
J Exp Med. 1993 Oct 1;178(4):1459-63. doi: 10.1084/jem.178.4.1459.
Abstract
Immunoglobulins drive efficient antigen capture by antigen presenting cells for processing and presentation on class II MHC-molecules. High affinity antibody/antigen interactions are stable at endosomal/lysosomal pH thus altering the substrate for antigen processing. We show that this can result in strong suppression of presentation of some T cell epitopes. This effect was observed when the antibody specificity was a B cell surface Ig, or formed part of an immune complex. In the latter case the presence of the suppressing antibody boosts presentation of other T cell epitopes through enhanced uptake into Fc receptor bearing cells. The influence of bound antibodies on the outcome of antigen processing may influence with T cell epitopes dominate T cell responses and may change the focus of the response with time.
摘要
免疫球蛋白驱动抗原呈递细胞高效捕获抗原，以便在II类主要组织相容性复合体（MHC）分子上进行加工和呈递。高亲和力抗体/抗原相互作用在内体/溶酶体pH值下稳定，从而改变抗原加工的底物。我们发现，这可能导致某些T细胞表位的呈递受到强烈抑制。当抗体特异性为B细胞表面免疫球蛋白或构成免疫复合物的一部分时，会观察到这种效应。在后一种情况下，抑制性抗体的存在通过增强Fc受体阳性细胞的摄取，促进了其他T细胞表位的呈递。结合抗体对抗原加工结果的影响可能会影响哪些T细胞表位主导T细胞反应，并可能随时间改变反应的重点。
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