Riggs J E
Department of Neurology, West Virginia University School of Medicine, Morgantown, USA.
Arch Neurol. 1995 Jun;52(6):571-5. doi: 10.1001/archneur.1995.00540300043011.
Increasing primary malignant brain tumor mortality among the elderly in developed countries over the past three decades has been attributed to improved diagnostic techniques and increased environmental carcinogens.
To demonstrate that rising primary malignant brain tumor mortality among the elderly can be accounted for by differential survival.
Published United States mortality data from the National Center for Health Statistics, 1962 to 1989.
Age-specific primary malignant brain tumor mortality rates were determined for the age groups of more than 60 years old and compared with the population size of these age groups.
Increasing primary malignant brain tumor mortality rates among the oldest age groups in the United States from 1962 to 1989 were directly proportional to the increasing population size of these age groups.
Comparisons between age-specific mortality rates are generally considered valid since they are inherently age- and sex-matched. Moreover, age-specific mortality rates should not be related to population size. Rather than implying improved diagnosis or enhanced carcinogenesis, these results suggest that differential survival and its effect on the surviving gene pool in an aging population is an alternative explanation for the observed increase in primary malignant brain tumor mortality among the elderly.
在过去三十年中，发达国家老年人原发性恶性脑肿瘤死亡率的上升归因于诊断技术的改进和环境致癌物的增加。
证明老年人原发性恶性脑肿瘤死亡率的上升可由差异生存来解释。
美国国家卫生统计中心1962年至1989年公布的死亡率数据。
确定60岁以上年龄组的年龄特异性原发性恶性脑肿瘤死亡率，并与这些年龄组的人口规模进行比较。
1962年至1989年期间，美国最年长年龄组原发性恶性脑肿瘤死亡率的上升与这些年龄组人口规模的增加成正比。
年龄特异性死亡率之间的比较通常被认为是有效的，因为它们本质上是年龄和性别匹配的。此外，年龄特异性死亡率不应与人口规模相关。这些结果并非意味着诊断的改善或致癌作用的增强，而是表明差异生存及其对老龄化人口中存活基因库的影响是观察到的老年人原发性恶性脑肿瘤死亡率增加的另一种解释。
