不孕夫妇生殖道中的巨细胞病毒感染与病毒脱落

Cytomegalovirus infection and viral shedding in the genital tract of infertile couples.

作者信息

Yang Y S, Ho H N, Chen H F, Chen S U, Shen C Y, Chang S F, Huang E S, Wu C W

机构信息

Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Republic of China.

出版信息

J Med Virol. 1995 Feb;45(2):179-82. doi: 10.1002/jmv.1890450212.

DOI:10.1002/jmv.1890450212

PMID:7775936

Abstract

The prevalence of cytomegalovirus (CMV) infection and viral shedding in infertile couples in Taiwan and its role in infertility were studied. Two hundred fifty couples were enrolled in this study. Anti-CMV IgG was measured in serum samples from these infertile couples. Viral shedding examined by DNA hybridization was detected in semen from the husband and cervical mucus from the wife. Anti-CMV IgG was detected in 249 (99.6%) of the 250 male serum samples and in 247 (98.9%) of the 250 female serum samples. Viral shedding was detectable in 83 (33.5%) of 248 semen samples and 83 (33.7%) of 246 cervical mucus samples by dot-blot DNA hybridization assay. Semen quality was not apparently affected by the existence of viral shedding. The co-shedding rate in semen and cervical mucus was high (15.9%). It is concluded that the seroprevalence and genital tract viral shedding were relatively high in infertile couples in Taiwan. Viral shedding did not affect the semen quality. Nevertheless, screening of donor semen is recommended.

摘要

对台湾不孕夫妇中巨细胞病毒（CMV）感染及病毒排出情况及其在不孕中的作用进行了研究。本研究纳入了250对夫妇。检测了这些不孕夫妇血清样本中的抗CMV IgG。通过DNA杂交检测病毒排出情况，在丈夫的精液和妻子的宫颈黏液中进行检测。在250份男性血清样本中有249份（99.6%）检测到抗CMV IgG，在250份女性血清样本中有247份（98.9%）检测到。通过斑点印迹DNA杂交分析，在248份精液样本中有83份（33.5%）、246份宫颈黏液样本中有83份（33.7%）检测到病毒排出。精液质量显然不受病毒排出存在的影响。精液和宫颈黏液中的共同排出率很高（15.9%）。得出结论，台湾不孕夫妇中的血清阳性率和生殖道病毒排出率相对较高。病毒排出不影响精液质量。尽管如此，仍建议对供精进行筛查。