Agata N, Ohta M, Mori M, Isobe M
Nagoya City Public Health Research Institute, Japan.
FEMS Microbiol Lett. 1995 Jun 1;129(1):17-20. doi: 10.1016/0378-1097(95)00119-P.
A vacuole-formation substance, cereulide of Bacillus cereus, is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.
蜡样芽孢杆菌的空泡形成物质——蜡样芽胞杆菌溶血素，是一种动物催吐毒素。口服和腹腔注射蜡样芽胞杆菌溶血素均在新型催吐动物模型——臭鼩中引起剂量依赖性呕吐。迷走神经切断术或5-羟色胺3（5-HT3）受体拮抗剂可完全消除这种催吐作用。因此，蜡样芽胞杆菌溶血素通过5-HT3受体并刺激迷走神经传入而引起呕吐。我们还发现，纯化的蜡样芽胞杆菌溶血素可导致人喉表皮样癌细胞（HEp-2细胞）的线粒体肿胀。
