[Lipid peroxides and vitamin E in plasma and plasma lipoproteins in blood of patients with chronic hemodialysis].

To investigate a possible oxidative modifications of plasma lipoproteins in chronic hemodialyzed patients, lipid peroxide concentrations in plasma and in VLDL, LDL and HDL were investigated in 40 patients receiving regular dialysis treatment (RDT). Additionally, vitamin E in this patients was also determined. The serum and lipoprotein lipid peroxides concentrations were significantly increased in RDT in comparison with 36 healthy subjects. The concentrations of the main lipoprotein antioxidant--vitamin E were significantly lower in RDT patients. There was an inverse correlation (r = -0,767; p < 0.02) between vitamin E and peroxides concentration in LDL. Furthermore, a significant increase of lipid peroxides in LDL were observed after hemodialysis. The results indicates vitamin E deficits in patients undergoing chronic hemodialysis.