尿舒张素与心钠素对肾脏作用的比较：钠状态变化的影响

Comparison of the renal effects of urodilatin and atrial natriuretic factor: effect of changes in sodium status.

作者信息

Yates N A, McDougall J G

机构信息

Howard Florey Institute, University of Melbourne, Parkville, Vic., Australia.

出版信息

Exp Nephrol. 1994 Sep-Oct;2(5):281-5.

PMID:7812733

Abstract

Urodilatin is an amino terminally extended form of atrial natriuretic factor (ANF) which is resistant to enzymatic cleavage by renal neutral endopeptidase (NEP: EC 3.4.24.11). The renal effects of infusion into the renal artery of equimolar doses of urodilatin or ANF have been compared following changes in Na status in conscious sheep. In all conditions urodilatin was a more potent natriuretic stimulus than was ANF and the natriuretic response to urodilatin was modulated by sodium status in the same way as the response to ANF: diminished by sodium depletion and enhanced by sodium loading. This study does not support the hypothesis that changes in NEP activity contribute to the modulation of the natriuretic response to ANF which is observed with modification of sodium status.

摘要

尿舒张素是心房利钠因子（ANF）氨基末端延伸形式，对肾中性内肽酶（NEP：EC 3.4.24.11）的酶解作用具有抗性。在清醒绵羊钠状态发生变化后，比较了向肾动脉输注等摩尔剂量尿舒张素或ANF对肾脏的影响。在所有情况下，尿舒张素都是比ANF更强效的利钠刺激物，并且对尿舒张素的利钠反应与对ANF的反应一样，受钠状态调节：钠耗竭时减弱，钠负荷时增强。本研究不支持以下假说，即NEP活性变化有助于调节钠状态改变时观察到的对ANF的利钠反应。