颅面畸形的病因发病机制。
Etiopathogenesis of craniofacial anomalies.
作者信息
Vander Kolk C A, Beaty T
机构信息
Johns Hopkins University School of Medicine, Baltimore, Maryland.
出版信息
Clin Plast Surg. 1994 Oct;21(4):481-8.
This article reviews the current information available on the etiopathogenesis of craniofacial anomalies with a particular emphasis on craniosynostosis. The incidence of various types of craniosynostosis is presented, along with an overview of the causes of malformations and deformations. The basic development of cranial sutures and fusion is explored as a background for the exploration of advances in genetic and molecular biology. This information lays the foundation for our understanding of craniofacial deformities and their response to surgical treatment described in the the other articles of this issue.
本文综述了目前关于颅面畸形病因学的现有信息，尤其着重于颅缝早闭。文中介绍了各种类型颅缝早闭的发病率，以及畸形和变形原因的概述。作为探索遗传和分子生物学进展的背景，探讨了颅缝的基本发育和融合情况。这些信息为我们理解本期其他文章中所述的颅面畸形及其手术治疗反应奠定了基础。
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