非酯化脂肪酸对2型（非胰岛素依赖型）糖尿病患者分离的骨骼肌中胰岛素刺激的葡萄糖转运的影响。

Effects of non-esterified fatty acids on insulin-stimulated glucose transport in isolated skeletal muscle from patients with type 2 (non-insulin-dependent) diabetes mellitus.

作者信息

Galuska D, Nolte L, Wahlström E, Smedegaard Kristensen J S, Wallberg-Henriksson H, Zierath J R

机构信息

Department of Clinical Physiology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.

出版信息

Acta Diabetol. 1994 Sep;31(3):169-72. doi: 10.1007/BF00570374.

DOI:10.1007/BF00570374

PMID:7827358

Abstract

The influence of elevated levels of oleate on insulin-stimulated 3-0-methylglucose transport was assessed in vitro, in isolated skeletal muscle obtained from patients with type 2 (non-insulin-dependent) diabetes mellitus (n = 7) and control subjects (n = 8). An increase in oleate levels from 0.3 to 1.0 mmol/l induced a 3.7-fold increase in the rate of oleate oxidation (P < 0.01) in skeletal muscle from control subjects. However, the rate of insulin-stimulated 3-0-methylglucose transport was not altered in isolated skeletal muscle from the control subjects or the type 2 diabetic patients following exposure to 1.0 mmol/l oleate. This observation indicates that elevation of non-esterified fatty acids to a high physiological level has no inhibitory effect on glucose transport.

摘要

在体外，对从2型（非胰岛素依赖型）糖尿病患者（n = 7）和对照受试者（n = 8）获取的离体骨骼肌进行研究，评估升高的油酸水平对胰岛素刺激的3 - O - 甲基葡萄糖转运的影响。油酸水平从0.3 mmol/l增加到1.0 mmol/l时，对照受试者骨骼肌中油酸氧化速率增加了3.7倍（P < 0.01）。然而，在暴露于1.0 mmol/l油酸后，对照受试者和2型糖尿病患者的离体骨骼肌中胰岛素刺激的3 - O - 甲基葡萄糖转运速率并未改变。这一观察结果表明，非酯化脂肪酸升高到较高生理水平对葡萄糖转运没有抑制作用。