十二指肠溃疡穿孔手术患者的胃酸研究
Gastric acid study in patients operated on for perforated duodenal ulcer.
作者信息
Lala A K, Rai P C, Ramachandran K, Jain S, Chaudhury R
机构信息
Department of Surgery, Safdarjang Hospital, New Delhi.
出版信息
Indian J Gastroenterol. 1994 Oct;13(4):135-6.
OBJECTIVES
To determine the acid secretory status of patients operated on for perforated duodenal ulcer, with or without prior history suggestive of acid-peptic disease.
METHOD
Basal and peak acid output were measured in 48 patients with perforated duodenal ulcer who were treated by simple closure alone, 10 patients with uncomplicated chronic duodenal ulcer and 30 normal controls. Patients operated on for perforated duodenal ulcer were analyzed according to presence (or absence) and duration of prior history of acid-peptic disease.
RESULTS
Peak acid output was similar in controls and patients with perforated duodenal ulcer with no prior symptoms. However, patients with prior symptoms had significantly higher peak acid output, similar to those with uncomplicated duodenal ulcer.
CONCLUSION
Patients with perforated duodenal ulcer with no antecedent history of acid-peptic disease have normal gastric acid output. These patients may therefore have other etiological factors for their ulcers.
目的
确定因十二指肠溃疡穿孔接受手术治疗的患者的胃酸分泌状况，无论其是否有提示酸相关性疾病的既往史。
方法
对48例仅接受单纯缝合治疗的十二指肠溃疡穿孔患者、10例无并发症的慢性十二指肠溃疡患者和30例正常对照者测量基础胃酸分泌量和最大胃酸分泌量。对因十二指肠溃疡穿孔接受手术治疗的患者，根据是否存在酸相关性疾病既往史及其持续时间进行分析。
结果
对照组与无既往症状的十二指肠溃疡穿孔患者的最大胃酸分泌量相似。然而，有既往症状的患者最大胃酸分泌量显著更高，与无并发症的十二指肠溃疡患者相似。
结论
无酸相关性疾病既往史的十二指肠溃疡穿孔患者胃酸分泌正常。因此，这些患者的溃疡可能有其他病因。
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