1,2,3,4-四氢异喹啉-4,6,8-三醇衍生物作为潜在β-肾上腺素能阻滞剂的制备及其活性
Preparation and activity of derivatives of 1,2,3,4-tetrahydroisoquinoline- 4,6,8-triol, as potential beta-adrenergic blockers.
作者信息
Brzezińska E
机构信息
Institute of Chemistry and Technology of Drugs, School of Medicine, Lódź, Poland.
出版信息
Acta Pol Pharm. 1994;51(2):137-41.
PMID:7863786
Abstract
The new derivatives of 1,2,3,4-tetrahydroisoquinoline-4,6,8-triol were synthesized as a potential beta-adrenergic blockers. These compounds were obtained by simple modification of beta-adrenergic agonists (terbutaline, orciprenaline, fenoterole) and evaluated pharmacologically for their activity and binding to beta-adrenoreceptor.
摘要
合成了1,2,3,4-四氢异喹啉-4,6,8-三醇的新衍生物作为潜在的β-肾上腺素能阻滞剂。这些化合物通过对β-肾上腺素能激动剂（特布他林、奥西那林、非诺特罗）进行简单修饰而获得，并对其活性及与β-肾上腺素受体的结合进行了药理学评估。
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