Effects of 5-fluorouracil derivatives on papillomas induced by application of 7,12-dimethylbenz(a)anthracene in mice.
作者信息
Sakamoto S, Matsubara M, Kudo H, Suzuki S, Liu L, Nakayama T, Mitamura T, Nagasawa H
机构信息
Medical Research Institute, Tokyo Medical and Dental University, Japan.
出版信息
Anticancer Res. 1994 Nov-Dec;14(6B):2515-9.
PMID:7872675
Abstract
We examined the effects of an application of 5-fluorouracil (5-FU) ointment and a chronic oral administration of 1-(2-tetrahydrofuryl)-5-FU plus uracil (UFT) on 7,12-dimethyl-benz(a)-anthracene-induced squamous cell papillomas in mice. Although application of 5-FU ointment reduced the growth of papillomas slightly, chronic oral administration of UFT could prevent tumorigenesis and suppress the growth of papillomas, resulting in the reduction of the tumorous viability and DNA synthesis.
摘要
相似文献
1
Effects of 5-fluorouracil derivatives on papillomas induced by application of 7,12-dimethylbenz(a)anthracene in mice.
Anticancer Res. 1994 Nov-Dec;14(6B):2515-9.
2
Suppression by kampo medicine, sho-saiko-to, on papillomas induced by 7,12-dimethylbenz(a)anthracene in mice.汉方药小柴胡汤对小鼠7,12-二甲基苯并(a)蒽诱导的乳头状瘤的抑制作用。
Am J Chin Med. 1994;22(3-4):267-74. doi: 10.1142/S0192415X94000322.
3
4
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.兰他定对小鼠皮肤肿瘤和小鼠肝肿瘤的抗肿瘤促进活性。
Planta Med. 1997 Jun;63(3):272-4. doi: 10.1055/s-2006-957673.
5
6
Effects of 5-fluorouracil derivative UFT on thymidylate synthetase and thymidine kinase in rat colorectal tumors.5-氟尿嘧啶衍生物优福定对大鼠结肠直肠肿瘤中胸苷酸合成酶和胸苷激酶的影响。
Anticancer Res. 1999 Jan-Feb;19(1A):245-50.
7
1-(2-Tetrahydrofuryl)-5-fluorouracil in combination with uracil suppresses mammary carcinogenesis and growth of tumors induced with 7,12-dimethylbenz[a]anthracene in rats.1-（2-四氢呋喃基）-5-氟尿嘧啶与尿嘧啶联合使用可抑制大鼠由7,12-二甲基苯并[a]蒽诱导的乳腺癌发生和肿瘤生长。
Anticancer Drugs. 1996 Feb;7(2):199-203. doi: 10.1097/00001813-199602000-00009.
8
Chemopreventive action by an extract from Brassica compestris (var Sarason) on 7,12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice.油菜（品种Sarason）提取物对7,12-二甲基苯并(a)蒽诱导的小鼠皮肤乳头状瘤形成的化学预防作用。
Phytother Res. 1999 May;13(3):261-3. doi: 10.1002/(SICI)1099-1573(199905)13:3<261::AID-PTR441>3.0.CO;2-5.
9
Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling.有证据表明，来自小鼠的皮肤致癌物引发的上皮细胞处于静止状态而非活跃循环状态。
Cancer Res. 1997 Aug 15;57(16):3436-43.
10
Effects of long-term administration of UFT plus leucovorin on colorectal tumors induced with 1,2-dimethylhydrazine in rats.长期给予优福定联合亚叶酸钙对大鼠1,2-二甲基肼诱导的结直肠癌的影响。
Anticancer Res. 1999 Nov-Dec;19(6B):5139-42.
Zotero 插件