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[胚胎神经组织的异种移植(形态学和免疫学方面)]

[The xenogeneic transplantation of embryonic nerve tissue (the morphological and immunological aspects)].

作者信息

Gilerovich E G

出版信息

Morfologiia. 1993 Mar-Apr;104(3-4):11-26.

PMID:7889152
Abstract

An analysis of the morphological and immunological aspects of xenotransplantation has shown that the xenotransplantation is a model for investigation of a wide range of problems of neurobiology: specific immune reactions in the brain and mechanisms of its immune privilege, conditions facilitating the take of transplants and mechanisms underlying autoimmune diseases of the CNS when the degenerative phase of the disease is accompanied by a cellular immune response. The use of xenotransplantations for studying potencies of the embryonic nerve tissues of man allowed to give grounds and to practically employ the method of treatment of parkinsonism. The first results of clinical use of the method obtained at the Institute of Experimental Medicine have shown its positive effects.

摘要

对异种移植的形态学和免疫学方面的分析表明,异种移植是研究神经生物学诸多问题的一个模型:大脑中的特异性免疫反应及其免疫豁免机制、促进移植成功的条件以及中枢神经系统自身免疫性疾病在疾病退行性阶段伴有细胞免疫反应时的潜在机制。利用异种移植来研究人类胚胎神经组织的潜能,为帕金森病的治疗方法提供了依据并得以实际应用。实验医学研究所获得的该方法临床应用的初步结果已显示出其积极效果。

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