提高原发性十二指肠癌患者的可切除性及生存率。

Improving resectability and survival in patients with primary duodenal carcinoma.

作者信息

Delcore R, Thomas J H, Forster J, Hermreck A S

机构信息

Department of Surgery, University of Kansas Medical Center, Kansas City 66160-7309.

出版信息

Am J Surg. 1993 Dec;166(6):626-30; discussion 630-1. doi: 10.1016/s0002-9610(05)80668-3.

DOI:10.1016/s0002-9610(05)80668-3

PMID:7903846

Abstract

Of 35 patients with primary duodenal carcinoma (PDC), 13 were treated between 1960 and 1974 (group I) and 22 between 1975 and 1990 (group II). PDCs were found in the first 5 portions of the duodenum (14%), second 18 (51%), third 8 (23%), and fourth 4 (12%). Five patients (38%) in group I were deemed to have unresectable disease compared with only one patient (5%) in group II. Eight patients (62%) in group I underwent resection by either pancreatoduodenectomy (4) or segmental resection (4), and 20 patients (95%) in group II had pancreatoduodenectomy (17) or segmental resection (3). Operative mortality was 31% in group I and 0% in group II. Mean survival was 7 months (range: 0 to 22 months) in group I and 48 months (range: 6 to 218 months) in group II. None of the patients in group I survived for 2 years, whereas the 5-year survival for patients in group II was 62%. This experience suggests that resectability, operative mortality, and survival in patients with PDCs have improved markedly in recent years.

摘要

在35例原发性十二指肠癌（PDC）患者中，13例于1960年至1974年接受治疗（I组），22例于1975年至1990年接受治疗（II组）。PDC位于十二指肠的前5段（14%）、第二段18例（51%）、第三段8例（23%）和第四段4例（12%）。I组中有5例（38%）被认为患有无法切除的疾病，而II组中只有1例（5%）。I组中有8例（62%）接受了胰十二指肠切除术（4例）或节段性切除术（4例），II组中有20例（95%）接受了胰十二指肠切除术（17例）或节段性切除术（3例）。I组的手术死亡率为31%，II组为0%。I组的平均生存期为7个月（范围：0至22个月），II组为48个月（范围：6至218个月）。I组中没有患者存活2年，而II组患者的5年生存率为62%。这一经验表明，近年来PDC患者的可切除性、手术死亡率和生存率有了显著改善。