c-erbB-2癌蛋白表达与宫颈鳞状细胞癌的不良预后相关。
c-erbB-2 Oncoprotein expression is associated with poor prognosis in squamous cell carcinoma of the cervix.
作者信息
Oka K, Nakano T, Arai T
机构信息
Section of Clinical Laboratory, National Institute of Radiological Sciences Hospital, Chiba, Japan.
出版信息
Cancer. 1994 Feb 1;73(3):664-71. doi: 10.1002/1097-0142(19940201)73:3<668::aid-cncr2820730327>3.0.co;2-d.
BACKGROUND
A polyclonal antihuman c-erbB-2 oncoprotein antibody recognized c-erbB-2 oncoprotein in routinely formaldehyde-fixed, paraffin-embedded specimens.
METHODS
Specimens taken from 192 patients with Stage III squamous cell carcinoma of the cervix treated with radiation therapy alone were investigated for c-erbB-2 oncoprotein expression using an immunohistochemical method.
RESULTS
Cancer cells that were positive for c-erbB-2 oncoprotein showed a surface membrane staining pattern. Of the 192 patients, 143 were negative for c-erbB-2 oncoprotein, 12 were weakly positive or ambiguous, 31 were positive, and 6 were strongly positive. The 5-year survival rate of the 155 patients who tested c-erbB-2 negative or weakly positive was significantly better than that of the 37 patients whose results were positive or strongly positive (61% versus 41%, P = 0.022).
CONCLUSION
c-erbB-2 Oncoprotein expression in cancer cells may imply a poor prognosis for patients with Stage III squamous cell carcinoma of the cervix treated with radiation therapy alone.
背景
一种多克隆抗人c-erbB-2癌蛋白抗体可识别常规甲醛固定、石蜡包埋标本中的c-erbB-2癌蛋白。
方法
采用免疫组化方法对192例仅接受放射治疗的III期宫颈鳞状细胞癌患者的标本进行c-erbB-2癌蛋白表达研究。
结果
c-erbB-2癌蛋白阳性的癌细胞呈现细胞膜染色模式。192例患者中，143例c-erbB-2癌蛋白阴性，12例弱阳性或结果不明确，31例阳性，6例强阳性。155例c-erbB-2检测为阴性或弱阳性患者的5年生存率显著高于37例结果为阳性或强阳性的患者（61%对41%，P = 0.022）。
结论
癌细胞中c-erbB-2癌蛋白表达可能提示仅接受放射治疗的III期宫颈鳞状细胞癌患者预后不良。
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