多药耐药相关糖蛋白在成人急性淋巴细胞白血病中的表达
The expression of the multidrug resistance related glycoprotein in adult acute lymphoblastic leukemia.
作者信息
Savignano C, Geromin A, Michieli M, Damiani D, Michelutti A, Melli C, Fanin R, Baccarani M
机构信息
Division and Chair of Hematology, Udine University Hospital, Italy.
出版信息
Haematologica. 1993 Sep-Oct;78(5):261-3.
BACKGROUND
More than 50% of adults with acute lymphoblastic leukemia (ALL) actually die with resistant leukemia. The multidrug resistance (MDR) related P170 glycoprotein may be involved in treatment failure.
METHODS
P170 content of leukemic cells was assayed by immunocytochemistry with the MRK-16 monoclonal antibody in 41 consecutive cases of adult ALL (27 at onset and 14 at relapse).
RESULTS
Positive cells were found in 11/14 cases at relapse and in 18/27 cases at onset. All cases with a high WBC, FAB L3, B-mature phenotype, and t(9; 22) were positive. In the 27 patients who were studied at onset and were treated with the same protocol, the overall failure rate was 44% in negative cases and 83% in positive cases.
CONCLUSION
P170 overexpression may contribute to drug resistance and to chemotherapy failure in adult ALL.
背景
超过50%的急性淋巴细胞白血病（ALL）成年患者实际上死于耐药性白血病。多药耐药（MDR）相关的P170糖蛋白可能与治疗失败有关。
方法
采用MRK-16单克隆抗体通过免疫细胞化学法检测41例成年ALL患者（27例初发，14例复发）白血病细胞中的P170含量。
结果
复发时11/14例、初发时18/27例发现阳性细胞。所有白细胞计数高、FAB L3、B成熟表型和t(9;22)的病例均为阳性。在27例初发时接受相同方案治疗的患者中，阴性病例的总体失败率为44%，阳性病例为83%。
结论
P170过表达可能导致成年ALL患者产生耐药性并导致化疗失败。
Zotero 插件