人类免疫缺陷病毒（HIV）糖蛋白120对无脊椎动物神经元的选择性作用。
Selective effects of human immunodeficiency virus (HIV) gp120 on invertebrate neurons.
作者信息
Stefano G B, Sawada M, Smith E M, Hughes T K
机构信息
Old Westbury Neuroscience Research Institute, State University of New York at Old Westbury 11568-0210.
出版信息
Cell Mol Neurobiol. 1993 Dec;13(6):569-77. doi: 10.1007/BF00711557.
Abstract
- HIV gp120 selectively reduces the glutamate-induced inward current and the acetylcholine-induced outward current in specific and identified Aplysia neurons without affecting dopamine (DA)- and serotonin (5-HT)-induced responses. 2. gp120 specifically decreases DA levels without significantly altering norepinephrine and 5-HT levels in Mytilus pedal ganglia. 3. The gp120-associated decrease in DA levels in Mytilus is dose dependent and exhibits a threshold level. 4. The alteration of in vitro DA levels is specific for gp120 since anti-gp120 blocks the effect. 5. gp120 and its effects appear to be stable due to the duration of treatment and the failure of secondary effects to materialize following antibody treatment.
摘要
- 人类免疫缺陷病毒糖蛋白120（HIV gp120）可选择性降低特定且已识别的海兔神经元中谷氨酸诱导的内向电流以及乙酰胆碱诱导的外向电流，而不影响多巴胺（DA）和5-羟色胺（5-HT）诱导的反应。2. gp120可特异性降低贻贝足神经节中的多巴胺水平，而对去甲肾上腺素和5-羟色胺水平无显著影响。3. 贻贝中与gp120相关的多巴胺水平降低呈剂量依赖性，并表现出阈值水平。4. 体外多巴胺水平的改变对gp120具有特异性，因为抗gp120可阻断该效应。5. 由于治疗持续时间以及抗体治疗后未出现继发效应，gp120及其效应似乎是稳定的。
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